|Full Name||phosphorylated adaptor for RNA export|
|Product Description||Rabbit Polyclonal antibody to PHAX (phosphorylated adaptor for RNA export)|
|Background||A phosphoprotein adapter involved in the XPO1-mediated U snRNA export from the nucleus. Bridge components required for U snRNA export, the cap binding complex (CBC)-bound snRNA on the one hand and the GTPase Ran in its active GTP-bound form together with the export receptor XPO1 on the other. Its phosphorylation in the nucleus is required for U snRNA export complex assembly and export, while its dephosphorylation in the cytoplasm causes export complex disassembly. It is recycled back to the nucleus via the importin alpha/beta heterodimeric import receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Its compartmentalized phosphorylation cycle may also contribute to the directionality of export. Binds strongly to m7G-capped U1 and U5 small nuclear RNAs (snRNAs) in a sequence-unspecific manner and phosphorylation-independent manner (By similarity). Plays also a role in the biogenesis of U3 small nucleolar RNA (snoRNA). Involved in the U3 snoRNA transport from nucleoplasm to Cajal bodies. Binds strongly to m7G-capped U3, U8 and U13 precursor snoRNAs and weakly to trimethylated (TMG)-capped U3, U8 and U13 snoRNAs. Binds also to telomerase RNA. |
|Synonyms||FLJ13193 antibody, RNUXA antibody, PHAX antibody, RNA U small nuclear RNA export adapter protein antibody, phosphorylated adapter RNA export protein antibody, "RNA U, small nuclear RNA export adapter (phosphorylation regulated) antibody", "RNA U, small nuclear RNA export adaptor (phosphorylation regulated) antibody", phosphorylated adaptor for RNA export antibody|
|Cellular Localization||Nucleus , nucleoplasm , Cajal body , Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PHAX. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (92%), Chicken (82%), Rhesus Monkey (98%), Bovine (95%)|