|Full Name||egl nine homolog 1 (C. elegans)|
|Product Description||Rabbit Polyclonal antibody to EGLN1 (egl nine homolog 1 (C. elegans))|
|Background||The protein encoded by this gene catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. HIF is a transcriptional complex that plays a central role in mammalian oxygen homeostasis. This protein functions as a cellular oxygen sensor, and under normal oxygen concentration, modification by prolyl hydroxylation is a key regulatory event that targets HIF subunits for proteasomal destruction via the von Hippel-Lindau ubiquitylation complex. Mutations in this gene are associated with erythrocytosis familial type 3 (ECYT3). [provided by RefSeq]|
|Synonyms||ZMYND6 Antibody , egl nine homolog 1 (C. elegans) Antibody , PHD2 Antibody , HPH-2 Antibody , ECYT3 Antibody , C1orf12 Antibody , SM20 Antibody , HIF-PH2 Antibody , HIFPH2 Antibody , HPH2 Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human EGLN1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (94%), Bovine (96%)|