|Full Name||egl nine homolog 3 (C. elegans)|
|Product Description||Rabbit Polyclonal antibody to PHD3 (egl nine homolog 3 (C. elegans))|
|Background||Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF-1 alpha at 'Pro-564', and HIF-2 alpha. Functions as a cellular oxygen sensor and, under normoxic conditions, targets HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. May play a role in cell growth regulation in muscle cells and in apoptosis in neuronal tissue. Promotes cell death through a caspase-dependent mechanism.|
|Synonyms||FLJ21620 antibody, HIFPH3 antibody, MGC125998 antibody, MGC125999 antibody, PHD3 antibody, EGLN3 antibody, egl nine-like protein 3 isoform antibody, prolyl hydroxylase domain-containing protein 3 antibody, egl nine homolog 3 antibody, HIF prolyl hydroxylase 3 antibody, hypoxia-inducible factor prolyl hydroxylase 3 antibody, HPH-3 antibody, HIF-PH3 antibody, HPH-1 antibody, HIF-prolyl hydroxylase 3 antibody, egl nine homolog 3 (C. elegans) antibody|
|Immunogen||Full length human PHD3 Recombinant protein.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (96%), Rat (96%), Rhesus Monkey (99%), Bovine (97%)|