|Full Name||phosphoinositide-3-kinase, class 2, alpha polypeptide|
|Product Description||Rabbit Polyclonal antibody to PI3 kinase C2 alpha (phosphoinositide-3-kinase, class 2, alpha polypeptide)|
|Background||The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq]|
|Synonyms||CPK antibody, DKFZp686L193 antibody, MGC142218 antibody, PI3-K-C2(ALPHA) antibody, PI3-K-C2A antibody, PIK3C2A antibody, ptdIns-3-kinase C2 subunit alpha antibody, C2-containing phosphatidylinositol kinase antibody, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha antibody, PI3K-C2alpha antibody, phosphoinositide 3-kinase-C2-alpha antibody, PI3K-C2-alpha antibody, phosphoinositide-3-kinase, class 2, alpha polypeptide antibody|
|Cellular Localization||Cell membrane , Golgi apparatus , Cytoplasmic vesicle , clathrin-coated vesicle , Nucleus , Cytoplasm |
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PI3K C2 alpha. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (100%), Rat (100%)|