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1 .GTX104640 PI3 kinase C2 alpha antibody [C3], C-term

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PI3 kinase C2 alpha antibody [C3], C-term


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsICC/IF, IHC-P, WB
  • Species reactivityHuman
  • Publication  ( 1 )
Cat No: GTX104640
Package Price Qty
25 μlUSD 119.00
100 μlUSD 319.00
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  • Anti-PI3 kinase C2 alpha antibody [C3], C-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX104640
  • Anti-PI3 kinase C2 alpha antibody [C3], C-term used in IHC (Formalin-fixed paraffin-embedded sections). GTX104640
  • Anti-PI3 kinase C2 alpha antibody [C3], C-term used in Western Blot (WB). GTX104640
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  • Application Information: PI3 kinase C2 alpha antibody [C3], C-term

Catalog Number GTX104640
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Publication ( 1 )
Product Name PI3 kinase C2 alpha antibody [C3], C-term
See all PI3 kinase C2 alpha products
ApplicationsICC/IF, IHC-P, WB
Application Note
Suggested dilutionReference
Immunocytochemistry/ Immunofluorescence (ICC/IF)1:100-1:1000* Y
IHC (Formalin-fixed paraffin-embedded sections)1:100-1:1000*  
Western Blot (WB)1:500-1:3000*  
Not tested in other applications.
*Optimal dilutions/concentrations should be determined by the researcher.
Predicted Target Size191 kDa (note) IsoForm (3)
Positive ControlsA431
Form SuppliedLiquid
Concentration0.8 mg/ml (Please refer to the vial label for the specific concentration)
PurificationPurified by antigen-affinity chromatography.

  • Specifications: PI3 kinase C2 alpha antibody [C3], C-term

Full Namephosphoinositide-3-kinase, class 2, alpha polypeptide
BackgroundThe protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to membranes, and may also mediate protein-protein interactions. The PI3-kinase activity of this protein is not sensitive to nanomolar levels of the inhibitor wortmanin. This protein was shown to be able to be activated by insulin and may be involved in integrin-dependent signaling. [provided by RefSeq]
SynonymsCPK antibody, DKFZp686L193 antibody, MGC142218 antibody, PI3-K-C2(ALPHA) antibody, PI3-K-C2A antibody, PIK3C2A antibody, ptdIns-3-kinase C2 subunit alpha antibody, C2-containing phosphatidylinositol kinase antibody, phosphatidylinositol-4-phosphate 3-kinase C2 domain-containing subunit alpha antibody, PI3K-C2alpha antibody, phosphoinositide 3-kinase-C2-alpha antibody, PI3K-C2-alpha antibody, phosphoinositide-3-kinase, class 2, alpha polypeptide antibody
Cellular LocalizationCell membrane , Golgi apparatus , Cytoplasmic vesicle , clathrin-coated vesicle , Nucleus , Cytoplasm
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenCarrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PI3K C2 alpha. The exact sequence is proprietary.
Antigen SpeciesHuman
Species ReactivityHuman
Predicted Cross Reactivity species Predicted cross-reactivity:
    Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
    Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
Mouse, Rat
Predict Reactivity NoteMouse (100%), Rat (100%)
ConjugationUnconjugated

  • Storage Conditions: PI3 kinase C2 alpha antibody [C3], C-term

Storage Buffer0.1M Tris, 0.1M Glycine, 10% Glycerol (pH7). 0.01% Thimerosal was added as a preservative.
Storage InstructionKeep as concentrated solution. Aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Cancer > Type of cancer > Endometrial
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PI3 kinase C2 alpha antibody [C3], C-term validated data
  • Anti-PI3 kinase C2 alpha antibody [C3], C-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX104640
    • GTX104640 ICC/IF Image
      Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed A431, using PI3K C2 alpha(GTX104640) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with GTX11304 (Red) at 1:500.
      Top
  • Anti-PI3 kinase C2 alpha antibody [C3], C-term used in IHC (Formalin-fixed paraffin-embedded sections). GTX104640
    • GTX104640 IHC-P Image
      PI3K C2 alpha antibody [C3], C-term detects PIK3C2A protein at cytosol on human hepatoma by immunohistochemical analysis.
      Sample: Paraffin-embedded hepatoma.
      PI3K C2 alpha antibody [C3], C-term (GTX104640) dilution: 1:200.
      Top
  • Anti-PI3 kinase C2 alpha antibody [C3], C-term used in Western Blot (WB). GTX104640
    • GTX104640 WB Image
      Sample (30 µg of whole cell lysate)
      A: A431 (GTX27909)
      5% SDS PAGE
      GTX104640 diluted at 1:1000
      The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
      Top
  • Anti-PI3 kinase C2 alpha antibody [C3], C-term used in Immunocytochemistry/ Immunofluorescence (ICC/IF). GTX104640
    • GTX104640 ICC/IF Image
      Confocal immunofluorescence analysis (Olympus FV10i) of paraformaldehyde-fixed A431, using PI3K C2 alpha(GTX104640) antibody (Green) at 1:500 dilution. Alpha-tubulin filaments were labeled with GTX11304 (Red) at 1:500.
      Top
  • Anti-PI3 kinase C2 alpha antibody [C3], C-term used in IHC (Formalin-fixed paraffin-embedded sections). GTX104640
    • GTX104640 IHC-P Image
      PI3K C2 alpha antibody [C3], C-term detects PIK3C2A protein at cytosol on human hepatoma by immunohistochemical analysis.
      Sample: Paraffin-embedded hepatoma.
      PI3K C2 alpha antibody [C3], C-term (GTX104640) dilution: 1:200.
      Top
  • Anti-PI3 kinase C2 alpha antibody [C3], C-term used in Western Blot (WB). GTX104640
    • GTX104640 WB Image
      Sample (30 µg of whole cell lysate)
      A: A431 (GTX27909)
      5% SDS PAGE
      GTX104640 diluted at 1:1000
      The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
      Top
Back to Top
  • Reference for PI3 kinase C2 alpha antibody [C3], C-term
Application References Application Reactivity
Nigorikawa K et al. Involvement of class II phosphoinositide 3-kinase α-isoform in antigen-induced degranulation in RBL-2H3 cells. PLoS One 9 (10):e111698 (2014). ICC/IF
Target Bioinfo/ Predicted Isoform Cross Reactivity
SpeciesGene nameGene IDSwissProtOMIMIsoform (mRNA)Protein Accession#MW
Homo sapiensPIK3C2A5286O00443, B0LPH2603601NP_001308307190.71
Homo sapiensPIK3C2A5286O00443, B0LPH2603601NP_001308309148.42
Homo sapiensPIK3C2A5286O00443, B0LPH2603601NM_002645NP_002636190.71

Cross-react Bioinfo
SpeciesGene nameGene IDSwissProtIsoform (mRNA)Protein Accession#MW
Mus musculusPik3c2a18704Q61194NM_011083NP_035213190.78
Rattus norvegicusPik3c2a361632NM_001108500NP_001101970190.95
    *MSDS
    MSDS-Glycerol.pdf
    MSDS-Thimerosal.pdf
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