|Full Name||protein inhibitor of activated STAT, 4|
|Product Description||Rabbit Polyclonal antibody to PIASy (protein inhibitor of activated STAT, 4)|
|Background||Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. |
|Synonyms||FLJ12419 antibody, MGC35296 antibody, PIASY antibody, Piasg antibody, ZMIZ6 antibody, PIAS4 antibody, protein inhibitor of activated STAT protein PIASy antibody, PIAS-gamma antibody, "zinc finger, MIZ-type containing 6 antibody", protein inhibitor of activated STAT protein gamma antibody, protein inhibitor of activated STAT protein 4 antibody, E3 SUMO-protein ligase PIAS4 antibody, "protein inhibitor of activated STAT, 4 antibody"|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PIASy. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Chimpanzee (100%), Bovine (100%)|