| Full Name | protein inhibitor of activated STAT 4 |
| Background | Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Promotes PARK7 sumoylation. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. |
| Synonyms | PIAS-gamma antibody , PIASY antibody , Piasg antibody , ZMIZ6 antibody |
| Cellular Localization | Nucleus |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | This polyclonal antibody was developed against a mixture of synthetic peptides corresponding to amino acids 46-60 (KKIKELYETRYAKKNC) and 187-198 (YSDTSCPQEDQY) of human PIASg; GenBank no. AAD45155.1|AF164437_1. These sequences are 95% and 100% homologous in mouse and rat. |
| Antigen Species | Human |
| Species Reactivity | Human, Mouse, Rat |
| Conjugation | Unconjugated |