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1 .GTX13795 PIASy antibody

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PIASy antibody


  • Host / ClonalityRabbit Polyclonal
  • ApplicationsWB
  • Species reactivityHuman, Mouse, Rat
Cat No: GTX13795
Package Price Qty
100 μgUSD 319.00
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  • Anti-PIASy antibody used in Western Blot (WB). GTX13795
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  • Datasheet
  • Application Information: PIASy antibody

Catalog Number GTX13795
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Product Name PIASy antibody
See all PIASy products
ApplicationsWB
Application NoteWB: Use at a concentration of 1 - 2 μg/ml. Detects a band of approximately 55 kDa. Optimal dilutions/concentrations should be determined by the end user.
Concentration0.5 mg/ml (Please refer to the vial label for the specific concentration)
PurificationProtein G purified

  • Specifications: PIASy antibody

Full Nameprotein inhibitor of activated STAT, 4
BackgroundThe interaction of a cytokine with its specific cell surface receptor triggers the activation of intracellular signaling pathways that ultimately program the cellular response. The signal transducers and activators of transcription (STAT) proteins play important roles in the activation of these pathways. Recently, a family of proteins has been identified that inhibits activated STATS and are named as Protein Inhibitors of Activated STAT (PIAS). PIAS proteins comprise a family of five mammalian proteins, which have been identified as potentially important down regulators of the STAT-signaling pathway. The cDNA for mouse and human PIASg encodes a protein of 507 amino acids that is highly homologous to the human protein and is expressed in the mouse as early as d 7.5 of gestation. In situ hybridizations of staged mouse embryos localized the transcript for the PIAS gamma gene to the limbs, neuroepithelium, and the inner root sheath of the hair follicle, suggesting a role in the development of these structures. This protein is also present in hair follicle of human scalp hair and in monkey neuronal cells. Thus PIASg exhibits a highly selective pattern of expression, suggesting that it modulates the response of cells to developmental cues.
SynonymsFLJ12419, MGC35296, PIASY, Piasg, ZMIZ6
Cellular LocalizationNuclear
HostRabbit
ClonalityPolyclonal
IsotypeIgG
ImmunogenSynthetic peptides QLVQFDCSPELFKKIKE and KAVQVVLRICYS, corresponding to amino acids 44-60 and 187-198 of Human PAIAS gamma.
Antigen SpeciesHuman
Species ReactivityHuman, Mouse, Rat
ConjugationUnconjugated

  • Storage Conditions: PIASy antibody

Storage BufferPreservative: 0.02% Sodium Azide; Constituents: 0.2% Gelatin, PBS
Storage InstructionKeep as concentrated solution. Store at 4ºC short term. For extended storage aliquot and store at -20ºC or below. Avoid freeze-thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Neuroscience > Signaling > Wnt singnaling
  • Signal Transduction > Signaling through proteolysis > Wnt
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PIASy antibody validated data
  • Anti-PIASy antibody used in Western Blot (WB). GTX13795
    • GTX13795 WB Image
      Western blot analysis of PAIASg in A) human liver, B) mouse liver, C) rat liver and D) human Jurkat lysate at 5 ug/ml.
      Top
  • Anti-PIASy antibody used in Western Blot (WB). GTX13795
    • GTX13795 WB Image
      Western blot analysis of PAIASg in A) human liver, B) mouse liver, C) rat liver and D) human Jurkat lysate at 5 ug/ml.
      Top
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All products are for research use only—Not for use in diagnostic procedures.