|Full Name||paired-like homeodomain 2|
|Product Description||Rabbit Polyclonal antibody to PITX2 (paired-like homeodomain 2)|
|Background||This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]|
|Synonyms||ARP1 antibody, Brx1 antibody, IDG2 antibody, IGDS antibody, IGDS2 antibody, IHG2 antibody, IRID2 antibody, MGC111022 antibody, MGC20144 antibody, Otlx2 antibody, PTX2 antibody, RGS antibody, RIEG antibody, RIEG1 antibody, RS antibody, PITX2 antibody, solurshin antibody, homeobox protein PITX2 antibody, paired-like homeodomain transcription factor 2 antibody, ALL1-responsive protein ARP1 antibody, pituitary homeo box 2 antibody, rieg bicoid-related homeobox transcription factor 1 antibody, pituitary homeobox 2 antibody, all1-responsive gene 1 antibody, paired-like homeodomain 2 antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PITX2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Zebrafish, Japanese medaka, Xenopus Tropicalis, Pig, Chicken, Bovine|
|Predict Reactivity Note||Mouse (96%), Zebrafish (87%), Japanese medaka (86%), Xenopus Tropicalis (89%), Pig (97%), Chicken (93%), Bovine (97%)|