|Full Name||paired-like homeodomain 2|
|Product Description||Rabbit Polyclonal antibody to PITX2 (paired-like homeodomain 2)|
|Background||This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. The encoded protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein plays a role in the terminal differentiation of somatotroph and lactotroph cell phenotypes, is involved in the development of the eye, tooth and abdominal organs, and acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin. Mutations in this gene are associated with Axenfeld-Rieger syndrome, iridogoniodysgenesis syndrome, and sporadic cases of Peters anomaly. A similar protein in other vertebrates is involved in the determination of left-right asymmetry during development. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]|
|Synonyms||IGDS2 Antibody, PTX2 Antibody, Brx1 Antibody, ARP1 Antibody, RIEG1 Antibody, IHG2 Antibody, paired-like homeodomain 2 Antibody, IRID2 Antibody, RGS Antibody, Otlx2 Antibody, IGDS Antibody, IDG2 Antibody, RS Antibody, RIEG Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human PITX2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Mouse (93%)|