|Full Name||protein kinase, cAMP-dependent, regulatory, type II, beta|
|Product Description||Rabbit Polyclonal antibody to PKA 2 beta (protein kinase, cAMP-dependent, regulatory, type II, beta)|
|Background||cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells. Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity. The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol. [provided by RefSeq]|
|Synonyms||PRKAR2 antibody, RII-BETA antibody, PRKAR2B antibody, cAMP-dependent protein kinase type II-beta regulatory subunit antibody, cAMP-dependent protein kinase type II-beta regulatory chain antibody, H_RG363E19.2 antibody, WUGSC:H_RG363E19.2 antibody, "protein kinase, cAMP-dependent, regulatory, type II, beta antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PKA 2 beta. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (96%), Bovine (99%)|