|Full Name||protein kinase, cAMP-dependent, catalytic, alpha|
|Product Description||Rabbit Polyclonal antibody to PKA C alpha (protein kinase, cAMP-dependent, catalytic, alpha)|
|Background||cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is a member of the Ser/Thr protein kinase family and is a catalytic subunit of cAMP-dependent protein kinase. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]|
|Synonyms||MGC102831 antibody, MGC48865 antibody, PKACA antibody, PRKACA antibody, protein kinase A catalytic subunit antibody, "cAMP-dependent protein kinase catalytic subunit alpha, isoform 1 antibody", cAMP-dependent protein kinase catalytic subunit alpha antibody, PKA C-alpha antibody, "protein kinase, cAMP-dependent, catalytic, alpha antibody"|
|Cellular Localization||Cytoplasm (By similarity) , Nucleus (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PKA C alpha. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Dog, Rabbit, Sheep, Bovine|
|Predict Reactivity Note||Rat (98%), Xenopus laevis (94%), Dog (99%), Rabbit (97%), Sheep (99%), Bovine (99%)|