|Full Name||protein kinase, cAMP-dependent, regulatory, type II, alpha|
|Product Description||Rabbit Polyclonal antibody to PKA R2 (protein kinase, cAMP-dependent, regulatory, type II, alpha)|
|Background||cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). [provided by RefSeq]|
|Synonyms||PKR2 Antibody, PRKAR2A Antibody, PRKAR2 Antibody, protein kinase, cAMP-dependent, regulatory, type II, alpha Antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PKA R2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (95%), Rat (95%), Pig (97%), Chimpanzee (99%), Bovine (96%)|