PKC alpha antibody
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||77 kDa (note)
|Positive Controls||H1299 , Jurkat , U87-MG , SK-N-SH , IMR32 , SK-N-AS , Neuro 2A , C8D30 , NIH-3T3 , Raw264.7 , C2C12 , PC-12 , Rat2|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||protein kinase C, alpha|
|Product Description||Rabbit Polyclonal antibody to PKC alpha (protein kinase C, alpha)|
|Background||Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been reported to play roles in many different cellular processes, such as cell adhesion, cell transformation, cell cycle checkpoint, and cell volume control. Knockout studies in mice suggest that this kinase may be a fundamental regulator of cardiac contractility and Ca(2+) handling in myocytes. [provided by RefSeq]|
|Synonyms||AAG6 antibody, MGC129900 antibody, MGC129901 antibody, PKC-alpha antibody, PKCA antibody, PRKACA antibody, PRKCA antibody, PKC-A antibody, protein kinase C alpha type antibody, aging-associated gene 6 antibody, "protein kinase C, alpha antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human PKC alpha. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Zebrafish, Xenopus laevis, Rabbit, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Zebrafish (89%), Xenopus laevis (92%), Rabbit (99%), Chicken (95%), Rhesus Monkey (100%), Bovine (98%)|