PKC beta antibody
|Applications||ICC/IF, IHC-P, WB, Functional Assay|
Not tested in other applications.
|IHC (Formalin-fixed paraffin-embedded sections)||1:100-1:1000*
| Functional Assay||Assay-dependent dilution
*Optimal dilutions/concentrations should be determined by the researcher.
|Predicted Target Size||77 kDa (note)
|Positive Controls||SK-N-SH , IMR32 , SK-N-AS|
(Please refer to the vial label for the specific concentration)|
|Purification||Purified by antigen-affinity chromatography.|
|Full Name||protein kinase C, beta|
|Product Description||Rabbit Polyclonal antibody to PKC beta (protein kinase C, beta)|
|Background||Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]|
|Synonyms||MGC41878 antibody, PKC-beta antibody, PKCB antibody, PRKCB1 antibody, PRKCB2 antibody, PRKCB antibody, protein kinase C beta type antibody, PKC-B antibody, "protein kinase C, beta 1 polypeptide antibody", "protein kinase C, beta antibody"|
|Cellular Localization||Cytoplasm (By similarity) , Membrane; Peripheral membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PKC beta. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rabbit, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (98%), Rabbit (98%), Rhesus Monkey (100%), Bovine (97%)|