|Full Name||protein kinase C, iota|
|Product Description||Rabbit Polyclonal antibody to PKC iota (protein kinase C, iota)|
|Background||This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq]|
|Synonyms||DXS1179E antibody, MGC26534 antibody, PKCI antibody, nPKC-iota antibody, PRKCI antibody, atypical protein kinase C-lambda/iota antibody, protein kinase C iota type antibody, PRKC-lambda/iota antibody, aPKC-lambda/iota antibody, "protein kinase C, iota antibody"|
|Cellular Localization||Cytoplasm , Membrane , Endosome , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PKC iota. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Bovine|
|Predict Reactivity Note||Mouse (97%), Rat (97%), Zebrafish (89%), Bovine (98%)|