|Full Name||protein kinase C, zeta|
|Product Description||Rabbit polyclonal antibody to PKC zeta (protein kinase C, zeta)|
|Background||Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]|
|Synonyms||PKC-ZETA antibody, PKC2 antibody, PRKCZ antibody, nPKC-zeta antibody, protein kinase C zeta type antibody, "protein kinase C, zeta antibody"|
|Cellular Localization||Cytoplasm , Endosome |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PKC zeta. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Pig, Rabbit, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (99%), Zebrafish (91%), Pig (99%), Rabbit (99%), Bovine (99%)|