|Full Name||phospholipase A2, group IVA (cytosolic, calcium-dependent)|
|Product Description||Rabbit Polyclonal antibody to PLA2G4A (phospholipase A2, group IVA (cytosolic, calcium-dependent))|
|Background||This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. [provided by RefSeq]|
|Synonyms||MGC126350 antibody, PLA2G4 antibody, cPLA2-alpha antibody, PLA2G4A antibody, phospholipase A2 group IVA antibody, calcium-dependent phospholipid-binding protein antibody, cytosolic phospholipase A2 antibody, phosphatidylcholine 2-acylhydrolase antibody, lysophospholipase antibody, cPLA2 antibody, "phospholipase A2, group IVA (cytosolic, calcium-dependent) antibody"|
|Cellular Localization||Cytoplasm , Cytoplasmic vesicle |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human PLA2G4A. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Rabbit, Bovine|
|Predict Reactivity Note||Rat (95%), Rabbit (92%), Bovine (92%)|