|Full Name||procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2|
|Product Description||Rabbit Polyclonal antibody to PLOD2 (procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2)|
|Background||The protein encoded by this gene is a membrane-bound homodimeric enzyme that is localized to the cisternae of the rough endoplasmic reticulum. The enzyme (cofactors iron and ascorbate) catalyzes the hydroxylation of lysyl residues in collagen-like peptides. The resultant hydroxylysyl groups are attachment sites for carbohydrates in collagen and thus are critical for the stability of intermolecular crosslinks. Some patients with Ehlers-Danlos syndrome type VIB have deficiencies in lysyl hydroxylase activity. Mutations in the coding region of this gene are associated with Bruck syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]|
|Synonyms||LH2 antibody, TLH antibody, PLOD2 antibody, lysyl hydroxylase 2 antibody, lysyl hydroxlase 2 antibody, lysine hydroxylase 2 antibody, "procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 antibody", telopeptide lysyl hydroxylase antibody, "procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 antibody"|
|Cellular Localization||Rough endoplasmic reticulum membrane; Peripheral membrane protein; Lumenal side |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PLOD2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Mouse, Rat, Bovine|
|Predict Reactivity Note||Human (100%), Mouse (89%), Rat (89%), Bovine (93%)|