|Full Name||promyelocytic leukemia|
|Product Description||Rabbit Polyclonal antibody to PML (promyelocytic leukemia)|
|Background||The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq]|
|Synonyms||MYL antibody, PP8675 antibody, RNF71 antibody, TRIM19 antibody, PML antibody, RING finger protein 71 antibody, "promyelocytic leukemia, inducer of antibody", tripartite motif protein TRIM19 antibody, protein PML antibody, promyelocytic leukemia protein antibody, tripartite motif-containing protein 19 antibody, probable transcription factor PML antibody, promyelocytic leukemia antibody|
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human PML. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Rhesus Monkey (98%), Chimpanzee (100%), Bovine (84%)|