|Full Name||polymerase (RNA) III (DNA directed) polypeptide E (80kD)|
|Product Description||Rabbit Polyclonal antibody to POLR3E (DNA-directed RNA polymerase III subunit RPC5)|
|Background||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Essential for efficient transcription from both the type 2 VAI and type 3 U6 RNA polymerase III promoters. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. |
|Synonyms||RPC5 antibody, SIN antibody, POLR3E antibody, RNA polymerase III subunit C5 antibody, DNA-directed RNA polymerase III subunit RPC5 antibody, DNA-directed RNA polymerase III 80 kDa polypeptide antibody, RNA polymerase III 80 kDa subunit RPC5 antibody, polymerase (RNA) III (DNA directed) polypeptide E (80kD) antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human POLR3E. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis|
|Predict Reactivity Note||Mouse (96%), Rat (96%), Zebrafish (82%), Xenopus laevis (80%)|