|Full Name||peroxisome proliferator-activated receptor delta|
|Product Description||Rabbit Polyclonal antibody to PPAR delta (peroxisome proliferator-activated receptor delta)|
|Background||This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PPAR gamma. It may function as an integrator of transcription repression and nuclear receptor signaling. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein related to APC/beta-catenin signaling pathway. Knockout studies in mice suggested the role of this protein in myelination of the corpus callosum, lipid metabolism, and epidermal cell proliferation. [provided by RefSeq]|
|Synonyms||FAAR antibody, MGC3931 antibody, NR1C2 antibody, NUC1 antibody, NUCI antibody, NUCII antibody, PPARB antibody, PPARD antibody, nuclear receptor subfamily 1 group C member 2 antibody, nuclear hormone receptor 1 antibody, PPAR-beta antibody, peroxisome proliferator-activated nuclear receptor beta/delta variant 2 antibody, PPAR-delta antibody, peroxisome proliferator-activated receptor delta antibody, peroxisome proliferator-activated receptor beta antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PPAR delta. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Japanese medaka, Dog, Pig, Rabbit, Chicken, Bovine|
|Predict Reactivity Note||Rat (94%), Japanese medaka (80%), Dog (98%), Pig (95%), Rabbit (95%), Chicken (90%), Bovine (96%)|