|Full Name||protein phosphatase, Mg2+/Mn2+ dependent, 1A|
|Product Description||Rabbit Polyclonal antibody to PPM1A (protein phosphatase, Mg2+/Mn2+ dependent, 1A)|
|Background||The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq]|
|Synonyms||FLJ42306 antibody, MGC9201 antibody, PP2C-ALPHA antibody, PP2CA antibody, PP2Calpha antibody, PPM1A antibody, protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform antibody, protein phosphatase 1A antibody, protein phosphatase, Mg2+/Mn2+ dependent, 1A antibody|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PPM1A. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Xenopus Tropicalis, Rabbit, Bovine|
|Predict Reactivity Note||Xenopus Tropicalis (89%), Rabbit (86%), Bovine (92%)|