|Full Name||protoporphyrinogen oxidase|
|Product Description||Rabbit Polyclonal antibody to PPOX (protoporphyrinogen oxidase)|
|Background||This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq]|
|Synonyms||MGC8485 antibody, PPO antibody, V290M antibody, VP antibody, PPOX antibody, protoporphyrinogen oxidase antibody|
|Cellular Localization||Mitochondrion inner membrane; Peripheral membrane protein; Intermembrane side |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PPOX. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (83%), Rat (81%), Bovine (90%)|