|Full Name||protein phosphatase 4, catalytic subunit|
|Product Description||Goat polyclonal antibody to PPP4C|
|Background||Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. |
|Synonyms||Protein phosphatase 4, catalytic subunit, PPX, PPP4C, PP4, PPH3, Protein phosphatase4, catalytic subunit, protein phosphatase4 (formerly X), catalytic subunit, protein phosphatase 4 (formerly X), catalytic subunit, PP4C, PPP4|
|Specificity||This antibody is specific for PPP4C.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Rabbit|