|Full Name||protein phosphatase 4, catalytic subunit|
|Product Description||Rabbit Polyclonal antibody to PPP4C (protein phosphatase 4, catalytic subunit)|
|Background||Protein phosphatase that is involved in many processes such as microtubule organization at centrosomes, maturation of spliceosomal snRNPs, apoptosis, tumor necrosis factor (TNF)-alpha signaling, activation of c-Jun N-terminal kinase MAPK8, regulation of histone acetylation, DNA damage checkpoint signaling, NF-kappa-B activation and cell migration. The PPP4C-PPP4R1 PP4 complex may play a role in dephosphorylation and regulation of HDAC3. The PPP4C-PPP4R2-PPP4R3A PP4 complex specifically dephosphorylates H2AFX phosphorylated on Ser-140 (gamma-H2AFX) generated during DNA replication and required for DNA DSB repair. Dephosphorylates NDEL1 at CDK1 phosphorylation sites and negatively regulates CDK1 activity in interphase. |
|Synonyms||PP4 antibody, PP4C antibody, PPH3 antibody, PPP4 antibody, PPX antibody, PPP4C antibody, serine/threonine-protein phosphatase 4 catalytic subunit antibody, PP-X antibody, "protein phosphatase X, catalytic subunit antibody", "protein phosphatase 4 (formerly X), catalytic subunit antibody", "protein phosphatase 4, catalytic subunit antibody"|
|Cellular Localization||Cytoplasm , Nucleus , Centrosome |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PPP4C. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Xenopus laevis, Rabbit, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Rat (99%), Xenopus laevis (99%), Rabbit (100%), Rhesus Monkey (100%), Bovine (100%)|