|Full Name||proline/arginine-rich end leucine-rich repeat protein|
|Product Description||Rabbit Polyclonal antibody to PRELP (proline/arginine-rich end leucine-rich repeat protein)|
|Background||The protein encoded by this gene is a leucine-rich repeat protein present in connective tissue extracellular matrix. This protein functions as a molecule anchoring basement membranes to the underlying connective tissue. This protein has been shown to bind type I collagen to basement membranes and type II collagen to cartilage. It also binds the basement membrane heparan sulfate proteoglycan perlecan. This protein is suggested to be involved in the pathogenesis of Hutchinson-Gilford progeria (HGP), which is reported to lack the binding of collagen in basement membranes and cartilage. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq]|
|Synonyms||proline/arginine-rich end leucine-rich repeat protein Antibody, MSTP161 Antibody, SLRR2A Antibody, MST161 Antibody|
|Cellular Localization||Secreted , extracellular space , extracellular matrix |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PRELP. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Human, Rat, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Human (100%), Rat (91%), Rhesus Monkey (99%), Bovine (91%)|