|Full Name||protein arginine methyltransferase 5|
|Product Description||Rabbit Polyclonal antibody to PRMT5 (protein arginine methyltransferase 5)|
|Background||Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Methylates SUPT5H. Mono- and dimethylates arginine residues of myelin basic protein (MBP) in vitro. Plays a role in the assembly of snRNP core particles. May play a role in cytokine-activated transduction pathways. Negatively regulates cyclin E1 promoter activity and cellular proliferation. May regulate the SUPT5H transcriptional elongation properties. May be part of a pathway that is connected to a chloride current, possibly through cytoskeletal rearrangement. Methylates histone H2A and H4 'Arg-3' during germ cell development. Methylates histone H3 'Arg-8', which may repress transcription. Methylates the Piwi proteins (PIWIL1, PIWIL2 and PIWIL4), methylation of Piwi proteins being required for the interaction with Tudor domain-containing proteins and subsequent localization to the meiotic nuage. Methylates RPS10.|
|Synonyms||HRMT1L5 antibody, IBP72 antibody, JBP1 antibody, SKB1 antibody, SKB1Hs antibody, PRMT5 antibody, SKB1 homolog antibody, protein arginine N-methyltransferase 5 antibody, shk1 kinase-binding protein 1 homolog antibody, 72 kDa ICln-binding protein antibody, HMT1 hnRNP methyltransferase-like 5 antibody, histone-arginine N-methyltransferase PRMT5 antibody, jak-binding protein 1 antibody, protein arginine methyltransferase 5 antibody|
|Cellular Localization||Cytoplasm , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PRMT5. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Japanese medaka, Pig, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Rat (98%), Zebrafish (85%), Japanese medaka (86%), Pig (100%), Rhesus Monkey (100%), Chimpanzee (99%), Bovine (98%)|