|Full Name||prion protein|
|Product Description||Rabbit Polyclonal antibody to PRP (prion protein)|
|Background||The protein encoded by this gene is a membrane glycosylphosphatidylinositol-anchored glycoprotein that tends to aggregate into rod-like structures. The encoded protein contains a highly unstable region of five tandem octapeptide repeats. This gene is found on chromosome 20, approximately 20 kbp upstream of a gene which encodes a biochemically and structurally similar protein to the one encoded by this gene. Mutations in the repeat region as well as elsewhere in this gene have been associated with Creutzfeldt-Jakob disease, fatal familial insomnia, Gerstmann-Straussler disease, Huntington disease-like 1, and kuru. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq]|
|Synonyms||ASCR antibody, CD230 antibody, CJD antibody, GSS antibody, MGC26679 antibody, PRIP antibody, PrP antibody, PrP27-30 antibody, PrP33-35C antibody, PrPc antibody, prion antibody, PRNP antibody, prion protein PrP antibody, prion-related protein antibody, CD230 antigen antibody, prion protein (p27-30) (Creutzfeldt-Jakob disease, Gerstmann-Strausler-Scheinker syndrome, fatal familial insomnia) antibody, major prion protein antibody, p27-30 antibody, prion protein antibody|
|Cellular Localization||Cell membrane; Lipid-anchor , GPI-anchor , Golgi apparatus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PRP. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Dog, Pig, Rabbit, Sheep, Rhesus Monkey, Chimpanzee, Bovine|
|Predict Reactivity Note||Rat (89%), Dog (89%), Pig (91%), Rabbit (92%), Sheep (91%), Rhesus Monkey (95%), Chimpanzee (98%), Bovine (91%)|