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PSA antibody [131-14234(TD11B3-4)]

Cat. No. GTX39421

Host

 Mouse

Clonality

 Monoclonal

Clone Name

 131-14234(TD11B3-4)

Isotype

 IgG1

Application

 IHC-P, IHC-Fr

Reactivity

 Human
Package
1 mg ($399)
See all PSA products

APPLICATION

Application Note

*Optimal dilutions/concentrations should be determined by the researcher.
Application Recommended Dilution
IHC-P Assay dependent
IHC-Fr Assay dependent
Not tested in other applications.

Calculated MW

29 kDa. ( Note )

Product Note

Human Prostate Specific Antigen (PSA). PSA is a tumor-associated antigen with a molecular weight of 34kDa. The antigen is found in normal prostatic epithelial lining cells of the ducts and acini, as well as inprimary and metastatic prostate carcinoma cells. PSA reactivity may also be found in BPH (benignprostatic hypertrophy), though the pattern of staining is different than that found in carcinoma tissues. Thestaining pattern ranges from cytoplasmic and secretory in normal and benign prostate to cytoplasmic withmembrane in neoplastic prostate.

PROPERTIES

Form

Liquid

Buffer

10mM Phosphate buffer, 150mM NaCl

Preservative

0.1% Sodium azide

Storage

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.

Concentration

5.14 mg/ml (Please refer to the vial label for the specific concentration.)

Antigen Species

Human

Immunogen

Prostate specific antigen (PSA) prepared from human seminal fluid

Purification

Protein A purified

Conjugation

Unconjugated

Note

For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.

Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.

TARGET

Synonyms

kallikrein related peptidase 3 , APS , KLK2A1 , PSA , hK3

Cellular Localization

Secreted

Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

Database

Research Area

REFERENCE

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REVIEW

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SDS
Sodium Azide.pdf
Package List Price ($)
$ 399