|Product Description||Rabbit polyclonal antibody to PSAP (prosaposin)|
|Background||This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq]|
|Synonyms||FLJ00245 antibody, GLBA antibody, MGC110993 antibody, SAP1 antibody, PSAP antibody, sphingolipid activator protein-1 antibody, proactivator polypeptide antibody, prosaposin antibody|
|Cellular Localization||Lysosome |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PSAP. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Pig (87%), Bovine (87%)|