|Full Name||proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7)|
|Product Description||Rabbit polyclonal antibody to PSMB8 (proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7))|
|Background||The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. This gene is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 3 (proteasome beta 5 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit. Two alternative transcripts encoding two isoforms have been identified; both isoforms are processed to yield the same mature subunit. [provided by RefSeq]|
|Synonyms||D6S216 antibody, D6S216E antibody, LMP7 antibody, MGC1491 antibody, PSMB5i antibody, RING10 antibody, PSMB8 antibody, proteasome subunit Y2 antibody, macropain subunit C13 antibody, proteasome subunit beta type-8 antibody, really interesting new gene 10 protein antibody, multicatalytic endopeptidase complex subunit C13 antibody, low molecular weight protein 7 antibody, proteasome subunit beta 5i antibody, proteasome component C13 antibody, proteasome catalytic subunit 3i antibody, low molecular mass protein 7 antibody, proteasome-related gene 7 antibody, protease component C13 antibody, "proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) antibody"|
|Cellular Localization||Cytoplasm (By similarity) , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PSMB8. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Japanese medaka, Xenopus laevis, Dog, Pig, Sheep, Bovine|
|Predict Reactivity Note||Japanese medaka (80%), Xenopus laevis (83%), Dog (91%), Pig (94%), Sheep (93%), Bovine (93%)|