|Full Name||proteasome (prosome, macropain) 26S subunit, ATPase, 3|
|Product Description||Rabbit Polyclonal antibody to PSMC3 (proteasome (prosome, macropain) 26S subunit, ATPase, 3)|
|Background||The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases that have chaperone-like activity. This subunit may compete with PSMC2 for binding to the HIV tat protein to regulate the interaction between the viral protein and the transcription complex. A pseudogene has been identified on chromosome 9. [provided by RefSeq]|
|Synonyms||MGC8487 antibody, TBP1 antibody, PSMC3 antibody, TBP-1 antibody, human immunodeficiency virus tat transactivator binding protein-1 antibody, proteasome subunit P50 antibody, proteasome 26S subunit ATPase 3 antibody, 26S proteasome AAA-ATPase subunit RPT5 antibody, 26S protease regulatory subunit 6A antibody, Tat-binding protein 1 antibody, "proteasome (prosome, macropain) 26S subunit, ATPase, 3 antibody"|
|Cellular Localization||Cytoplasm (Potential) , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PSMC3. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Japanese medaka, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (99%), Zebrafish (97%), Japanese medaka (99%), Chicken (100%), Rhesus Monkey (100%), Bovine (100%)|