|Full Name||proteasome (prosome, macropain) 26S subunit, ATPase, 6|
|Product Description||Rabbit Polyclonal antibody to PSMC6 (proteasome (prosome, macropain) 26S subunit, ATPase, 6)|
|Background||The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the ATPase subunits, a member of the triple-A family of ATPases which have a chaperone-like activity. Pseudogenes have been identified on chromosomes 8 and 12. [provided by RefSeq]|
|Synonyms||CADP44 antibody, MGC12520 antibody, P44 antibody, SUG2 antibody, p42 antibody, PSMC6 antibody, conserved ATPase domain protein 44 antibody, proteasome 26S subunit ATPase 6 antibody, 26S proteasome AAA-ATPase subunit RPT4 antibody, proteasome subunit p42 antibody, 26S protease regulatory subunit 10B antibody, 26S protease regulatory subunit S10B antibody, "proteasome (prosome, macropain) 26S subunit, ATPase, 6 antibody"|
|Cellular Localization||Cytoplasm (By similarity) , Nucleus |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PSMC6. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Chicken, Bovine|
|Predict Reactivity Note||Rat (100%), Zebrafish (99%), Xenopus laevis (99%), Chicken (99%), Bovine (100%)|