|Full Name||proteasome (prosome, macropain) 26S subunit, non-ATPase, 12|
|Product Description||Rabbit Polyclonal antibody to PSMD12 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 12)|
|Background||The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 3. [provided by RefSeq]|
|Synonyms||MGC75406 antibody, Rpn5 antibody, p55 antibody, PSMD12 antibody, 26S proteasome regulatory subunit RPN5 antibody, 26S proteasome regulatory subunit p55 antibody, 26S proteasome non-ATPase regulatory subunit 12 antibody, "proteasome (prosome, macropain) 26S subunit, non-ATPase, 12 antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PSMD12. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis, Chicken, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (99%), Rat (99%), Zebrafish (84%), Xenopus laevis (92%), Chicken (93%), Rhesus Monkey (100%), Bovine (99%)|