|Full Name||proteasome (prosome, macropain) 26S subunit, non-ATPase, 2|
|Product Description||Rabbit Polyclonal antibody to PSMD2 (26S proteasome non-ATPase regulatory subunit 2)|
|Background||The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes one of the non-ATPase subunits of the 19S regulator lid. In addition to participation in proteasome function, this subunit may also participate in the TNF signalling pathway since it interacts with the tumor necrosis factor type 1 receptor. A pseudogene has been identified on chromosome 1. [provided by RefSeq]|
|Synonyms||MGC14274 antibody, P97 antibody, Rpn1 antibody, S2 antibody, TRAP2 antibody, PSMD2 antibody, 26S proteasome regulatory subunit S2 antibody, protein 55.11 antibody, 26S proteasome non-ATPase regulatory subunit 2 antibody, 26S proteasome regulatory subunit RPN1 antibody, 55.11 protein antibody, tumor necrosis factor receptor-associated protein 2 antibody, tumor necrosis factor type 1 receptor-associated protein 2 antibody, 26S proteasome subunit p97 antibody, TNFR-associated protein 2 antibody, "proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PSMD2. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Rat, Zebrafish, Xenopus laevis, Pig, Chicken, Bovine|
|Predict Reactivity Note||Rat (100%), Zebrafish (91%), Xenopus laevis (92%), Pig (100%), Chicken (97%), Bovine (100%)|