|Full Name||proteasome (prosome, macropain) 26S subunit, non-ATPase, 8|
|Product Description||Rabbit Polyclonal antibody to PSMD8 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 8)|
|Background||The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a non-ATPase subunit of the 19S regulator. A pseudogene has been identified on chromosome 1. [provided by RefSeq]|
|Synonyms||HIP6 antibody, HYPF antibody, MGC1660 antibody, Nin1p antibody, Rpn12 antibody, S14 antibody, p31 antibody, PSMD8 antibody, 26S proteasome regulatory subunit S14 antibody, 26S proteasome regulatory subunit RPN12 antibody, 26S proteasome regulatory subunit p31 antibody, 26S proteasome non-ATPase regulatory subunit 8 antibody, "proteasome (prosome, macropain) 26S subunit, non-ATPase, 8 antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PSMD8. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Chimpanzee, Bovine|
|Predict Reactivity Note||Mouse (93%), Rat (90%), Zebrafish (84%), Chimpanzee (100%), Bovine (93%)|