|Full Name||proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)|
|Product Description||Rabbit Polyclonal antibody to PSME1 (proteasome (prosome, macropain) activator subunit 1 (PA28 alpha))|
|Background||The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the alpha subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three alpha and three beta subunits combine to form a heterohexameric ring. Two transcripts encoding different isoforms have been identified. [provided by RefSeq]|
|Synonyms||IFI5111 antibody, MGC8628 antibody, PA28A antibody, PA28alpha antibody, REGalpha antibody, PSME1 antibody, interferon-gamma IEF SSP 5111 antibody, 11S regulator complex subunit alpha antibody, proteasome activator subunit-1 antibody, 29-kD MCP activator subunit antibody, IGUP I-5111 antibody, proteasome activator complex subunit 1 antibody, 11S regulator complex alpha subunit antibody, activator of multicatalytic protease subunit 1 antibody, proteasome activator 28 subunit alpha antibody, REG-alpha antibody, interferon gamma up-regulated I-5111 protein antibody, interferon-gamma-inducible protein 5111 antibody, "proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PSME1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (94%), Rat (95%), Pig (98%), Rhesus Monkey (99%), Bovine (96%)|