|Full Name||patched 1|
|Product Description||Rabbit polyclonal antibody to PTCH1 (patched homolog 1 (Drosophila))|
|Background||This gene encodes a member of the patched gene family. The encoded protein is the receptor for sonic hedgehog, a secreted molecule implicated in the formation of embryonic structures and in tumorigenesis, as well as the desert hedgehog and indian hedgehog proteins. This gene functions as a tumor suppressor. Mutations of this gene have been associated with basal cell nevus syndrome, esophageal squamous cell carcinoma, trichoepitheliomas, transitional cell carcinomas of the bladder, as well as holoprosencephaly. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional splice variants have been described, but their full length sequences and biological validity cannot be determined currently. [provided by RefSeq]|
|Synonyms||BCNS antibody, FLJ26746 antibody, FLJ42602 antibody, HPE7 antibody, NBCCS antibody, PTC antibody, PTC1 antibody, PTCH antibody, PTCH11 antibody, PTCH1 antibody, PTCH protein -10 antibody, PTCH protein +4' antibody, patched homolog 1 antibody, PTCH protein +12b antibody, protein patched homolog 1 antibody, "PTCH protein -3,4,5 antibody", patched 1 antibody|
|Cellular Localization||Membrane; Multi-pass membrane protein|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PTCH1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Chicken, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Xenopus laevis (100%), Chicken (100%), Bovine (100%)|