|Full Name||phosphatase and tensin homolog|
|Product Description||Rabbit Polyclonal antibody to PTEN (phospho Thr366/pS370) (phosphatase and tensin homolog)|
|Background||This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT/PKB signaling pathway. [provided by RefSeq]|
|Synonyms||PTEN Antibody , BZS Antibody , phosphatase and tensin homolog Antibody , PTEN1 Antibody , CWS1 Antibody , 10q23del Antibody , GLM2 Antibody , TEP1 Antibody , MMAC1 Antibody , MHAM Antibody , DEC Antibody|
|Target||PTEN (phospho Thr366/Ser370)|
|Immunogen||Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human PTEN (phospho Thr366/Ser370). The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Xenopus laevis, Dog, Pig, Rhesus Monkey, Bovine|
|Predict Reactivity Note||Mouse (100%), Rat (100%), Xenopus laevis (100%), Dog (100%), Pig (100%), Rhesus Monkey (100%), Bovine (100%)|