|Full Name||pancreas specific transcription factor, 1a|
|Product Description||Rabbit Polyclonal antibody to PTF1A (pancreas specific transcription factor, 1a)|
|Background||This gene encodes a protein that is a component of the pancreas transcription factor 1 complex (PTF1) and is known to have a role in mammalian pancreatic development. The protein plays a role in determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. The protein is thought to be involved in the maintenance of exocrine pancreas-specific gene expression including elastase 1 and amylase. Mutations in this gene cause cerebellar agenesis and loss of expression is seen in ductal type pancreas cancers. [provided by RefSeq]|
|Synonyms||pancreas specific transcription factor, 1a Antibody , PTF1-p48 Antibody , bHLHa29 Antibody|
|Cellular Localization||Nucleus (By similarity) , Cytoplasm (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the C-terminus region of human PTF1A. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Zebrafish, Xenopus laevis|
|Predict Reactivity Note||Mouse (96%), Rat (95%), Zebrafish (86%), Xenopus laevis (81%)|