|Full Name||protein tyrosine phosphatase, non-receptor type 12|
|Product Description||Rabbit Polyclonal antibody to PTPN12 (protein tyrosine phosphatase, non-receptor type 12)|
|Background||The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a C-terminal PEST motif, which serves as a protein-protein interaction domain, and may regulate protein intracellular half-life. This PTP was found to bind and dephosphorylate the product of the oncogene c-ABL and thus may play a role in oncogenesis. This PTP was also shown to interact with, and dephosphorylate, various products related to cytoskeletal structure and cell adhesion, such as p130 (Cas), CAKbeta/PTK2B, PSTPIP1, and paxillin. This suggests it has a regulatory role in controlling cell shape and mobility. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq]|
|Synonyms||PTP-PEST antibody, PTPG1 antibody, PTPN12 antibody, tyrosine-protein phosphatase non-receptor type 12 antibody, protein-tyrosine phosphatase G1 antibody, "protein tyrosine phosphatase, non-receptor type 12 antibody"|
|Cellular Localization||Cytoplasm |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human PTPN12. The exact sequence is proprietary.|
|Species Reactivity||Human, Rat|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Xenopus laevis, Bovine|
|Predict Reactivity Note||Mouse (99%), Xenopus laevis (81%), Bovine (98%)|