|Full Name||protein tyrosine phosphatase, receptor type, N polypeptide 2|
|Product Description||Rabbit polyclonal antibody to R-PTP-N2 (protein tyrosine phosphatase, receptor type, N polypeptide 2)|
|Background||The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq]|
|Synonyms||IA-2beta antibody, IAR antibody, ICAAR antibody, PTPRP antibody, PTPRN2 antibody, tyrosine phosphatase IA-2 beta antibody, receptor-type tyrosine-protein phosphatase N2 antibody, IAR/receptor-like protein-tyrosine phosphatase antibody, islet cell autoantigen-related protein antibody, protein tyrosine phosphatase receptor pi antibody, phogrin antibody, "protein tyrosine phosphatase, receptor type, N polypeptide 2 antibody"|
|Cellular Localization||Membrane; Single-pass type I membrane protein |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PTPRN2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Human (100%)|