|Full Name||poliovirus receptor-related 1 (herpesvirus entry mediator C)|
|Product Description||Rabbit Polyclonal antibody to PVRL1 (poliovirus receptor-related 1 (herpesvirus entry mediator C))|
|Background||This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq]|
|Synonyms||PVRR Antibody , PRR Antibody , OFC7 Antibody , PVRR1 Antibody , poliovirus receptor-related 1 (herpesvirus entry mediator C) Antibody , SK-12 Antibody , HIgR Antibody , nectin-1 Antibody , ED4 Antibody , HVEC Antibody , CLPED1 Antibody , PRR1 Antibody , C|
|Cellular Localization||Isoform Alpha: Cell membrane; Single-pass type I membrane protein , Isoform Delta: Cell membrane; Single-pass type I membrane protein , Isoform Gamma: Secreted |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human PVRL1. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Dog, Pig|
|Predict Reactivity Note||Mouse (90%), Rat (89%), Dog (95%), Pig (96%)|