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Catalog Number
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GTX88474-PEP
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0
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Product Name
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PXR blocking peptide
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| Full Name | nuclear receptor subfamily 1 group I member 2 |
| Synonyms | SXR blocking peptide , PARQ blocking peptide , NR1I2 blocking peptide , ONR1 blocking peptide , PAR1 blocking peptide , PAR blocking peptide , PAR2 blocking peptide , PRR blocking peptide , SAR blocking peptide , BXR blocking peptide |
| Specificity | The peptide was used in the production of GTX88474. |
| Background | This gene product belongs to the nuclear receptor superfamily, members of which are transcription factors characterized by a ligand-binding domain and a DNA-binding domain. The encoded protein is a transcriptional regulator of the cytochrome P450 gene CYP3A4, binding to the response element of the CYP3A4 promoter as a heterodimer with the 9-cis retinoic acid receptor RXR. It is activated by a range of compounds that induce CYP3A4, including dexamethasone and rifampicin. Several alternatively spliced transcripts encoding different isoforms, some of which use non-AUG (CUG) translation initiation codon, have been described for this gene. Additional transcript variants exist, however, they have not been fully characterized. [provided by RefSeq, Jul 2008] |
| Species | Human |
| Region/Sequence | EQFAITLKSYIECNR |
| Applications | Apuri, Blocking, ELISA |
| Form Supplied | Lyophilized powder |
| Storage Buffer | Lyophilized from 5% (v/v) acetonitrile/H₂O. Reconstitute pellet in 200µl distilled water to obtain a 0.5mg/ml peptide solution. |
| Storage Instruction | Keep as concentrated solution. For short-term storage, store at 4° C (up to 10 days). For long-term storage, aliquot and store at -20° C or below. Avoid multiple freeze-thaw cycles. |
| Notes | For In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption. |
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