|Full Name||protein tyrosine kinase 2 beta|
|Product Description||Rabbit Polyclonal antibody to PYK2 |
|Background||This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]|
|Synonyms||CADTK Antibody , PTK Antibody , RAFTK Antibody , protein tyrosine kinase 2 beta Antibody , FAK2 Antibody , FADK2 Antibody , PKB Antibody , CAKB Antibody , PTK2B Antibody|
|Cellular Localization||Cytoplasm , Cell membrane |
|Immunogen||Recombinant protein encompassing a sequence within the center region of human PYK2. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Mouse, Rat, Bovine|
|Predict Reactivity Note||Mouse (92%), Rat (93%), Bovine (92%)|