Full Name | pancreatic and duodenal homeobox 1 |
Background | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
Synonyms | IUF1, IDX1, STF-1, IDX-1, STF1, MODY4, PDX-1, PDX1, STF 1, IDX 1, PDX 1 |
Specificity | GTX83919 is specific for amino acids 1-283 of human PDX1. |
Host | Mouse |
Clonality | Monoclonal |
Clone Name | 2A12 |
Isotype | IgG1 |
Immunogen | Recombinant protein expressed in E.coli corresponding to amino acids 1-283 of human PDX1. |
Antigen Species | Human |
Species Reactivity | Human |
Conjugation | Unconjugated |