| Full Name | pancreatic and duodenal homeobox 1 |
| Product Description | Mouse monoclonal antibody [2A12] to PDX1 |
| Background | Activates insulin, somatostatin, glucokinase, islet amyloid polypeptide and glucose transporter type 2 gene transcription. Particularly involved in glucose-dependent regulation of insulin gene transcription. Binds preferentially the DNA motif 5'-[CT]TAAT[TG]-3'. During development, specifies the early pancreatic epithelium, permitting its proliferation, branching and subsequent differentiation. At adult stage, required for maintaining the hormone-producing phenotype of the beta-cell. |
| Synonyms | IUF1, IDX1, STF-1, IDX-1, STF1, MODY4, PDX-1, PDX1, STF 1, IDX 1, PDX 1 |
| Specificity | GTX83919 is specific for amino acids 1-283 of human PDX1. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone Name | 2A12 |
| Target | PDX1 |
| Isotype | IgG1 |
| Immunogen | Recombinant protein expressed in E.coli corresponding to amino acids 1-283 of human PDX1. |
| Antigen Species | Human |
| Species Reactivity | Human |