|Product Description||Rabbit Polyclonal antibody to Periplakin (periplakin)|
|Background||The protein encoded by this gene is a component of desmosomes and of the epidermal cornified envelope in keratinocytes. The N-terminal domain of this protein interacts with the plasma membrane and its C-terminus interacts with intermediate filaments. Through its rod domain, this protein forms complexes with envoplakin. This protein may serve as a link between the cornified envelope and desmosomes as well as intermediate filaments. AKT1/PKB, a protein kinase mediating a variety of cell growth and survival signaling processes, is reported to interact with this protein, suggesting a possible role for this protein as a localization signal in AKT1-mediated signaling. [provided by RefSeq]|
|Synonyms||KIAA0568 antibody, MGC134872 antibody, PPL antibody, 190 kDa paraneoplastic pemphigus antigen antibody, periplakin antibody, 195 kDa cornified envelope precursor protein antibody|
|Cellular Localization||Cell junction , desmosome , Cytoplasm , cytoskeleton , Cell membrane (By similarity) , Nucleus (By similarity) , Mitochondrion (By similarity) |
|Immunogen||Recombinant protein encompassing a sequence within the N-terminus region of human Periplakin. The exact sequence is proprietary.|
|Species Reactivity||Human, Mouse|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Rat (91%)|