|Full Name||kallikrein B, plasma (Fletcher factor) 1|
|Product Description||Rabbit Polyclonal antibody to Plasma Kallikrein 1B (plasma kallikrein)|
|Background|| Plasma prekallikrein is a glycoprotein that participates in the surface-dependent activation of blood coagulation, fibrinolysis, kinin generation and inflammation. It is synthesized in the liver and secreted into the blood as a single polypeptide chain. Plasma prekallikrein is converted to plasma kallikrein by factor XIIa by the cleavage of an internal Arg-Ile bond. Plasma kallikrein therefore is composed of a heavy chain and a light chain held together by a disulphide bond. The heavy chain originates from the amino-terminal end of the zymogen and contains 4 tandem repeats of 90 or 91 amino acids. Each repeat harbors a novel structure called the apple domain. The heavy chain is required for the surface-dependent pro-coagulant activity of plasma kallikrein. The light chain contains the active site or catalytic domain of the enzyme and is homologous to the trypsin family of serine proteases. Plasma prekallikrein deficiency causes a prolonged activated partial thromboplastin time in patients. [provided by RefSeq]|
|Synonyms||KLK3 antibody, PPK antibody, KLKB1 antibody, plasma kallikrein antibody, kininogenin antibody, plasma kallikrein heavy chain antibody, plasma kallikrein light chain antibody, plasma prekallikrein antibody, Fletcher factor antibody, "kallikrein B, plasma (Fletcher factor) 1 antibody"|
|Immunogen||Recombinant protein encompassing a sequence within the center region of human Plasma Kallikrein 1B. The exact sequence is proprietary.|
|Predicted Cross Reactivity species Predicted cross-reactivity:|
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
|Predict Reactivity Note||Human (100%), Dog (82%)|