| Full Name | polycystic kidney disease 2 (autosomal dominant) |
| Background | This gene encodes a member of the polycystin protein family. The encoded protein contains multiple transmembrane domains, and cytoplasmic N- and C-termini. The protein may be an integral membrane protein involved in cell-cell/matrix interactions. The encoded protein may function in renal tubular development, morphology, and function, and may modulate intracellular calcium homoeostasis and other signal transduction pathways. This protein interacts with polycystin 1 to produce cation-permeable currents. Mutations in this gene have been associated with autosomal dominant polycystic kidney disease. [provided by RefSeq] |
| Synonyms | APKD2 antibody, MGC138466 antibody, MGC138468 antibody, PC2 antibody, PKD4 antibody, Pc-2 antibody, TRPP2 antibody, PKD2 antibody, autosomal dominant polycystic kidney disease type II protein antibody, polycystwin antibody, polycystin-2 antibody, "transient receptor potential cation channel, subfamily P, member 2 antibody", R48321 antibody, polycystic kidney disease 2 (autosomal dominant) antibody |
| Cellular Localization | Membrane; Multi-pass membrane protein |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant protein encompassing a sequence within the C-terminus region of human Polycystin 2. The exact sequence is proprietary. |
| Antigen Species | Human |
| Species Reactivity | Human |
Predicted Cross Reactivity species  Predicted cross-reactivity:
Predicted cross-reactivity is based on sequence homology, with greater than 80% immunogen sequence identity considered positive.
Please note that we are only able to guarantee products to work in applications and species in which they have been tested.
| Mouse, Rat, Zebrafish, Pig, Chicken, Bovine |
| Predict Reactivity Note | Mouse (92%), Rat (94%), Zebrafish (86%), Pig (98%), Chicken (92%), Bovine (97%) |
| Conjugation | Unconjugated |