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1 .GTX78229 PTBP1 antibody [SH54]

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PTBP1 antibody [SH54]


  • Host / ClonalityMouse Monoclonal
  • Clone NameSH54
  • ApplicationsICC/IF, IHC-P, WB
  • Species reactivityHuman
Cat No: GTX78229
Package Price Qty
100 μgUSD 319.00
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  • Datasheet
  • Application Information: PTBP1 antibody [SH54]

Catalog Number GTX78229
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Product Name PTBP1 antibody [SH54]
See all PTBP1 products
ApplicationsICC/IF, IHC-P, WB
Application NoteIHC-FFPE (2.5 ug/ml), IF (1-3 ug/ml), Western blot (1.0 ug/ml)
Form SuppliedLiquid

  • Specifications: PTBP1 antibody [SH54]

Full Namepolypyrimidine tract binding protein 1
BackgroundPolypyrimidine tract binding protein (PTB) is an abundant vertebrate hnRNP protein that functions as a splicing regulator with multiple targets. PTB exists as a 57 kDa protein that is found exclusively in the perinucleolar compartment (PNC) and regulates alternative splicing by binding to a specific pyrimidine tract sequence that is typically found near the 3' end of introns. The PNC in turn is a structure that is more prevalent in cancer cells than in normal cells. This latter observation suggests the possibility of using expression of PTB as a marker for tumor cells. In solution phase, PTB exists as a homodimer and in some cancer cells exists as two isoforms, the ratio of which appears to correlate with metastatic potential particularly in prostatic carcinoma. PTB is involved in the regulation of many different viral genomes such as that of hepatitis C virus.
SynonymsHNRNP-I, HNRNPI, HNRPI, MGC10830, MGC8461, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB, PTB 1, PTB T, HNRNP I, PTB1, PTBT
HostMouse
ClonalityMonoclonal
Clone NameSH54
IsotypeIgG1
ImmunogenMice were immunized with human HeLa nuclear extract and fusing the splenocytes with Sp2/0 mouse myeloma cells.
Antigen SpeciesHuman
Species ReactivityHuman
ConjugationUnconjugated

  • Storage Conditions: PTBP1 antibody [SH54]

Storage Buffer100 ug purified IgG1 with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.
Storage InstructionStore at -20º C. Avoid multiple freeze/thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Disease Related > Alzheimer's disease
  • Disease Related > Cardiovascular > Heart > Heart disease
  • Neuroscience > Disorder > Alzheimer's disease
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PTBP1 antibody [SH54] validated data
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All products are for research use only—Not for use in diagnostic procedures.