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  • Polypyrimidine Tract Binding Protein antibody [SH54]

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1 .GTX78229 Polypyrimidine Tract Binding Protein antibody [SH54]

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Polypyrimidine Tract Binding Protein antibody [SH54]


  • Host / ClonalityMouse Monoclonal
  • Clone NameSH54
  • ApplicationsICC/IF, IHC-P, WB
  • Species reactivityHuman
Cat No: GTX78229
Package Price Qty
100 μgUSD 319.00
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  • Datasheet

  • Application Information: Polypyrimidine Tract Binding Protein antibody [SH54]

Catalog Number GTX78229
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Product Name Polypyrimidine Tract Binding Protein antibody [SH54]
See all PTBP1 products
ApplicationsICC/IF, IHC-P, WB
Application NoteIHC-FFPE (2.5 ug/ml), IF (1-3 ug/ml), Western blot (1.0 ug/ml)
Form SuppliedLiquid

  • Specifications: Polypyrimidine Tract Binding Protein antibody [SH54]

Full Namepolypyrimidine tract binding protein 1
Product DescriptionMouse anti-Polypyrimidine Tract Binding Protein (SH54) monoclonal antibody
BackgroundPolypyrimidine tract binding protein (PTB) is an abundant vertebrate hnRNP protein that functions as a splicing regulator with multiple targets. PTB exists as a 57 kDa protein that is found exclusively in the perinucleolar compartment (PNC) and regulates alternative splicing by binding to a specific pyrimidine tract sequence that is typically found near the 3' end of introns. The PNC in turn is a structure that is more prevalent in cancer cells than in normal cells. This latter observation suggests the possibility of using expression of PTB as a marker for tumor cells. In solution phase, PTB exists as a homodimer and in some cancer cells exists as two isoforms, the ratio of which appears to correlate with metastatic potential particularly in prostatic carcinoma. PTB is involved in the regulation of many different viral genomes such as that of hepatitis C virus.
SynonymsHNRNP-I, HNRNPI, HNRPI, MGC10830, MGC8461, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB, PTB 1, PTB T, HNRNP I, PTB1, PTBT
HostMouse
ClonalityMonoclonal
Clone NameSH54
TargetPolypyrimidine Tract Binding Protein
IsotypeIgG1
ImmunogenMice were immunized with human HeLa nuclear extract and fusing the splenocytes with Sp2/0 mouse myeloma cells.
Antigen SpeciesHuman
Species ReactivityHuman

  • Storage Conditions: Polypyrimidine Tract Binding Protein antibody [SH54]

Storage Buffer100 ug purified IgG1 with 50% glycerol, 0.01% sodium azide and 1.0 mg/ml BSA.
Storage InstructionStore at -20º C. Avoid multiple freeze/thaw cycles.
NotesFor In vitro laboratory use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
ResearchArea
  • Disease Related > Alzheimer's disease
  • Disease Related > Cardiovascular > Heart > Heart disease
  • Neuroscience > Disorder > Alzheimer's disease
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Polypyrimidine Tract Binding Protein antibody [SH54] validated data
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