APPLICATION
Application Note
*Optimal dilutions/concentrations should be determined by the researcher.
| Application |
Recommended Dilution |
| 0.5 - 2 μg/mL |
| 2.5 μg/mL |
| Assay dependent |
Not tested in other applications.
Calculated MW
Positive Control
Human Brain Tissue Slide(GTX22203) , Human Brain Tissue Lysate(GTX27918)
PROPERTIES
Form
Liquid
Buffer
PBS
Preservative
0.02% Sodium azide
Storage
Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4ºC. For long-term storage, aliquot and store at -20ºC or below. Avoid multiple freeze-thaw cycles.
Concentration
1 mg/ml (Please refer to the vial label for the specific concentration.)
Antigen Species
Human
Immunogen
Presenilin1 antibody was raised against a 23 amino acid synthetic peptide from near the carboxy terminus of human presenilin1.The immunogen is located within amino acids 330 - 380 of Presenilin1.
Purification
Purified by antigen-affinity chromatography
Conjugation
Unconjugated
Note
For laboratory research use only. Not for any clinical, therapeutic, or diagnostic use in humans or animals. Not for animal or human consumption.
Purchasers shall not, and agree not to enable third parties to, analyze, copy, reverse engineer or otherwise attempt to determine the structure or sequence of the product.
TARGET
Synonyms
presenilin 1 , ACNINV3 , AD3 , FAD , PS-1 , PS1 , S182
Cellular Localization
Endoplasmic reticulum,Endoplasmic reticulum membrane,Golgi apparatus membrane,Cell membrane
Background
Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq, Aug 2008]
Database
Research Area
DATA IMAGES
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GTX31313 WB Image
WB analysis of human brain tissue lysate using GTX31313 Presenilin 1 antibody.
Working concentration : (A) 0.5, (B) 1, and (C) 2 μg/ml
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GTX31313 IHC-P Image
IHC-P analysis of human brain tissue using GTX31313 Presenilin 1 antibody.
Working concentration : 2.5 μg/ml
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GTX31313 IHC-P Image
IHC-P analysis of human brain tissue using GTX31313 Presenilin 1 antibody.
Working concentration : 20 μg/ml
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REFERENCE
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REVIEW
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